Immunogenic and tolerogenic cell death.
Ontology highlight
ABSTRACT:
SUBMITTER: Green DR
PROVIDER: S-EPMC2818721 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Immunogenic and tolerogenic cell death.
Green Douglas R DR Ferguson Thomas T Zitvogel Laurence L Kroemer Guido G
Nature reviews. Immunology 20090501 5
The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity. However, an effective immune response against host tissue is often needed to eliminate tumours following treatment with chemotherapeutic agents that trigger tumour cell death. Consequently, a central ...[more]
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