Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh EJ
PROVIDER: S-EPMC2818881 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Hsieh Edward J EJ Hoopmann Michael R MR MacLean Brendan B MacCoss Michael J MJ
Journal of proteome research 20100201 2
In shotgun proteomics, the analysis of tandem mass spectrometry data from peptides can benefit greatly from high mass accuracy measurements. In this study, we have evaluated two database search strategies which use high mass accuracy measurements of the peptide precursor ion. Our results indicate that peptide identifications are improved when spectra are searched with a wide mass tolerance window and precursor mass is used as a filter to discard incorrect matches. Database searches with a peptid ...[more]