Ontology highlight
ABSTRACT:
SUBMITTER: Hung KE
PROVIDER: S-EPMC2819006 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Hung Kenneth E KE Chung Daniel C DC
Drug discovery today. Disease mechanisms 20060101 4
Although there have been tremendous advances in the management of colorectal cancer (CRC), there is still a need for improved therapeutic approaches. On a molecular genetic level, CRC is one of the best-understood solid malignancies, and these insights can serve as a foundation for the design of novel targeted therapies. We present new genetic and epigenetic pathways that highlight the heterogeneous mechanisms in CRC pathogenesis, including the roles of the MYH DNA repair gene and of aberrant DN ...[more]