Ontology highlight
ABSTRACT:
SUBMITTER: Caputo F
PROVIDER: S-EPMC6861966 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Caputo Francesco F Santini Chiara C Bardasi Camilla C Cerma Krisida K Casadei-Gardini Andrea A Spallanzani Andrea A Andrikou Kalliopi K Cascinu Stefano S Gelsomino Fabio F
International journal of molecular sciences 20191028 21
Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is a heterogeneous disease, which can be classified into different subtypes, characterized by specific molecular and morphological alterations. In this context, BRAF mutations are found in about 10% of CRC patients and define a particular subtype, characterized by a dismal prognosis, with a median survival of less than 12 months. Chemotherapy plus bevacizumab is the current standard therapy in first- ...[more]