Ontology highlight
ABSTRACT:
SUBMITTER: Konig C
PROVIDER: S-EPMC2819678 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
König Cornelia C Maekawa Hiromi H Schiebel Elmar E
The Journal of cell biology 20100201 3
The mitotic exit network (MEN) is a spindle pole body (SPB)-associated, GTPase-driven signaling cascade that controls mitotic exit. The inhibitory Bfa1-Bub2 GTPase-activating protein (GAP) only associates with the daughter SPB (dSPB), raising the question as to how the MEN is regulated on the mother SPB (mSPB). Here, we show mutual regulation of cyclin-dependent kinase 1 (Cdk1) and the MEN. In early anaphase Cdk1 becomes recruited to the mSPB depending on the activity of the MEN kinase Cdc15. Co ...[more]