Ontology highlight
ABSTRACT:
SUBMITTER: Mayr C
PROVIDER: S-EPMC2819821 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Mayr Christine C Bartel David P DP
Cell 20090801 4
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene. Helping to explain this phenomenon, we found that when compared to similarly proliferating nontransformed cell lines, cancer cell lines often expressed substantial amounts of mRNA isoforms with shorter 3' untranslated regions (UTRs). These shorter isoforms usually resulted from al ...[more]