Ontology highlight
ABSTRACT:
SUBMITTER: Lusvarghi S
PROVIDER: S-EPMC2819988 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20091201 51
Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents. Guanine-rich peptide nucleic acid (PNA) oligomers bind to homologous DNA and RNA to form hetero-G-quadruplexes but can also bind to complementary cytosine-rich sequences to form heteroduplexes. In this study, we incorporated backbone modifications into G-rich PNAs to improve the selectivity for quadruplex versus duplex formation. Incorporation of ...[more]