Ontology highlight
ABSTRACT:
SUBMITTER: Sacho EJ
PROVIDER: S-EPMC2820111 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Sacho Elizabeth J EJ Kadyrov Farid A FA Modrich Paul P Kunkel Thomas A TA Erie Dorothy A DA
Molecular cell 20080101 1
MutL alpha, the heterodimeric eukaryotic MutL homolog, is required for DNA mismatch repair (MMR) in vivo. It has been suggested that conformational changes, modulated by adenine nucleotides, mediate the interactions of MutL alpha with other proteins in the MMR pathway, coordinating the recognition of DNA mismatches by MutS alpha and the activation of MutL alpha with the downstream events that lead to repair. Thus far, the only evidence for these conformational changes has come from X-ray crystal ...[more]