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Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

ABSTRACT: Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.

SUBMITTER: Maloney KN

PROVIDER: S-EPMC2820114 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

Maloney Katherine N KN Macmillan John B JB Kauffman Christopher A CA Jensen Paul R PR Dipasquale Antonio G AG Rheingold Arnold L AL Fenical William W

Organic letters 20091201 23

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM. ...[more]

PMID: 19883103

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