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Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.


ABSTRACT: Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

SUBMITTER: Jang KH 

PROVIDER: S-EPMC3821700 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.

Jang Kyoung Hwa KH   Nam Sang-Jip SJ   Locke Jeffrey B JB   Kauffman Christopher A CA   Beatty Deanna S DS   Paul Lauren A LA   Fenical William W  

Angewandte Chemie (International ed. in English) 20130617 30


Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria. ...[more]

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2008-11-30 | GSE13662 | GEO