Ontology highlight
ABSTRACT:
SUBMITTER: Donnelly MP
PROVIDER: S-EPMC2820164 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Donnelly Michael P MP Paschou Peristera P Grigorenko Elena E Gurwitz David D Mehdi Syed Qasim SQ Kajuna Sylvester L B SL Barta Csaba C Kungulilo Selemani S Karoma N J NJ Lu Ru-Band RB Zhukova Olga V OV Kim Jong-Jin JJ Comas David D Siniscalco Marcello M New Maria M Li Peining P Li Hui H Manolopoulos Vangelis G VG Speed William C WC Rajeevan Haseena H Pakstis Andrew J AJ Kidd Judith R JR Kidd Kenneth K KK
American journal of human genetics 20100128 2
The polymorphic inversion on 17q21, sometimes called the microtubular associated protein tau (MAPT) inversion, is an approximately 900 kb inversion found primarily in Europeans and Southwest Asians. We have identified 21 SNPs that act as markers of the inverted, i.e., H2, haplotype. The inversion is found at the highest frequencies in Southwest Asia and Southern Europe (frequencies of approximately 30%); elsewhere in Europe, frequencies vary from < 5%, in Finns, to 28%, in Orcadians. The H2 inve ...[more]