Ontology highlight
ABSTRACT:
SUBMITTER: Maze I
PROVIDER: S-EPMC2820240 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100101 5962
Cocaine-induced alterations in gene expression cause changes in neuronal morphology and behavior that may underlie cocaine addiction. In mice, we identified an essential role for histone 3 lysine 9 (H3K9) dimethylation and the lysine dimethyltransferase G9a in cocaine-induced structural and behavioral plasticity. Repeated cocaine administration reduced global levels of H3K9 dimethylation in the nucleus accumbens. This reduction in histone methylation was mediated through the repression of G9a in ...[more]