Ontology highlight
ABSTRACT:
SUBMITTER: Ayala G
PROVIDER: S-EPMC2820291 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Ayala Gustavo G Yan Jun J Li Rile R Ding Yi Y Thompson Timothy C TC Mims Martha P MP Hayes Teresa G TG MacDonnell Vivian V Lynch R Garret RG Frolov Anna A Miles Brian J BJ Wheeler Thomas M TM Harper J Wade JW Tsai Ming-Jer MJ Ittmann Michael M MM Kadmon Dov D
Clinical cancer research : an official journal of the American Association for Cancer Research 20081101 22
<h4>Purpose</h4>To assess the safety of administering bortezomib to patients undergoing a radical prostatectomy, to assess pathologic changes induced by bortezomib in prostate cancer specimen, and to verify alterations by the drug in proteasome protein targets.<h4>Experimental design</h4>Bortezomib is a proteasome inhibitor that has shown activity in vitro and in vivo in prostate cancer. We performed a neoadjuvant clinical trial of bortezomib in men with prostate cancer at high risk of recurrenc ...[more]