Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez L
PROVIDER: S-EPMC2820720 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Hernandez Lorena L Smirnova Tatiana T Kedrin Dmitriy D Wyckoff Jeffrey J Zhu Liyin L Stanley E Richard ER Cox Dianne D Muller William J WJ Pollard Jeffrey W JW Van Rooijen Nico N Segall Jeffrey E JE
Cancer research 20090317 7
An important step in the process of metastasis from the primary tumor is invasive spread into the surrounding stroma. Using an in vivo invasion assay, we have previously shown that imposed gradients of epidermal growth factor (EGF) or colony-stimulating factor-1 (CSF-1) can induce invasion through an EGF/CSF-1 paracrine loop between cancer cells and macrophages. We now report that invasion induced by other ligands also relies on this EGF/CSF-1 paracrine invasive loop. Using an in vivo invasion a ...[more]