Ontology highlight
ABSTRACT:
SUBMITTER: McRae S
PROVIDER: S-EPMC2820744 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
McRae Steven S Pagliai Fernando A FA Mohapatra Nrusingh P NP Gener Alejandro A Mahmou Asma Sayed Abdelgeliel AS Gunn John S JS Lorca Graciela L GL Gonzalez Claudio F CF
The Journal of biological chemistry 20091222 8
Acid phosphatase activity in the highly infectious intracellular pathogen Francisella tularensis is directly related with the ability of these bacteria to survive inside host cells. Pharmacological inactivation of acid phosphatases could potentially help in the treatment of tularemia or even be utilized to neutralize the infection. In the present work, we report inhibitory compounds for three of the four major acid phosphatases produced by F. tularensis SCHU4: AcpA, AcpB, and AcpC. The inhibitor ...[more]