Ontology highlight
ABSTRACT:
SUBMITTER: Lauriano CM
PROVIDER: S-EPMC384726 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Lauriano Crystal M CM Barker Jeffrey R JR Yoon Sang-Sun SS Nano Francis E FE Arulanandam Bernard P BP Hassett Daniel J DJ Klose Karl E KE
Proceedings of the National Academy of Sciences of the United States of America 20040309 12
Francisella tularensis is able to survive and grow within macrophages, a trait that contributes to pathogenesis. Several genes have been identified that are important for intramacrophage survival, including mglA and iglC. F. tularensis is also able to survive within amoebae. It is shown here that F. tularensis mglA and iglC mutant strains are not only defective for survival and replication within the macrophage-like cell line J774, but also within Acanthamoebae castellanii. Moreover, these strai ...[more]