Ontology highlight
ABSTRACT:
SUBMITTER: Hornak V
PROVIDER: S-EPMC2822010 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Hornak Viktor V Ahuja Shivani S Eilers Markus M Goncalves Joseph A JA Sheves Mordechai M Reeves Philip J PJ Smith Steven O SO
Journal of molecular biology 20091211 3
Structural restraints provided by solid-state NMR measurements of the metarhodopsin II intermediate are combined with molecular dynamics simulations to help visualize structural changes in the light activation of rhodopsin. Since the timescale for the formation of the metarhodopsin II intermediate (>1 ms) is beyond that readily accessible by molecular dynamics, we use NMR distance restraints derived from 13C dipolar recoupling measurements to guide the simulations. The simulations yield a workin ...[more]