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ABSTRACT:
SUBMITTER: Dutagaci B
PROVIDER: S-EPMC4137758 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Dutagaci Bercem B Becker-Baldus Johanna J Faraldo-Gómez José D JD Glaubitz Clemens C
Biochimica et biophysica acta 20140529 10
Ceramides play a key modulatory role in many cellular processes, which results from their effect on the structure and dynamics of biological membranes. In this study, we investigate the influence of C16-ceramide (C16) on the biophysical properties of DMPC lipid bilayers using solid-state NMR and atomistic molecular dynamics (MD) simulations. MD simulations and NMR measurements were carried out for a pure DMPC bilayer and for a 20% DMPC-C16 mixture. Calculated key structural properties, namely ar ...[more]