Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC2822278 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Chen Weiguo W Sivaprasad Umasundari U Tabata Yasuhiro Y Gibson Aaron M AM Stier Matthew T MT Finkelman Fred D FD Hershey Gurjit K Khurana GK
Journal of immunology (Baltimore, Md. : 1950) 20091201 12
Although mice have nanogram per milliliter serum levels of soluble (s) IL-13Ralpha2, humans lack sIL-13Ralpha2 in serum. Our data provide a mechanism for this biological divergence. In mice, discrete transcripts encoding soluble and membrane forms of IL-13Ralpha2 are generated by alternative splicing. We used small interfering RNA to specifically deplete the transcript encoding membrane (mem) IL-13Ralpha2 (full-length) or sIL-13Ralpha2 (DeltaEx10) in murine cells. Depletion of the full-length tr ...[more]