Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
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ABSTRACT:
SUBMITTER: Rubinstein MP
PROVIDER: S-EPMC1482584 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Rubinstein Mark P MP Kovar Marek M Purton Jared F JF Cho Jae-Ho JH Boyman Onur O Surh Charles D CD Sprent Jonathan J
Proceedings of the National Academy of Sciences of the United States of America 20060606 24
IL-15 is normally presented in vivo as a cell-associated cytokine bound to IL-15Ralpha. We show here that the biological activity of soluble IL-15 is much improved after interaction with recombinant soluble IL-15Ralpha; after injection, soluble IL-15/IL-15Ralpha complexes rapidly induce strong and selective expansion of memory-phenotype CD8(+) cells and natural killer cells. These findings imply that binding of IL-15Ralpha to IL-15 may create a conformational change that potentiates IL-15 recogn ...[more]
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