Bimodal gene expression patterns in breast cancer.
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ABSTRACT:
SUBMITTER: Bessarabova M
PROVIDER: S-EPMC2822536 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Bimodal gene expression patterns in breast cancer.
Bessarabova Marina M Kirillov Eugene E Shi Weiwei W Bugrim Andrej A Nikolsky Yuri Y Nikolskaya Tatiana T
BMC genomics 20100210
We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. ...[more]
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