Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors.
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ABSTRACT:
SUBMITTER: Voon V
PROVIDER: S-EPMC2822730 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors.
Voon Valerie V Pessiglione Mathias M Brezing Christina C Gallea Cecile C Fernandez Hubert H HH Dolan Raymond J RJ Hallett Mark M
Neuron 20100101 1
Pathological behaviors such as problem gambling or shopping are characterized by compulsive choice despite alternative options and negative costs. Reinforcement learning algorithms allow a computation of prediction error, a comparison of actual and expected outcomes, which updates our predictions and influences our subsequent choices. Using a reinforcement learning model, we show data consistent with the idea that dopamine agonists in susceptible individuals with Parkinson's disease increase the ...[more]
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