Ontology highlight
ABSTRACT:
SUBMITTER: Johnson PM
PROVIDER: S-EPMC2947358 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Nature neuroscience 20100328 5
We found that development of obesity was coupled with emergence of a progressively worsening deficit in neural reward responses. Similar changes in reward homeostasis induced by cocaine or heroin are considered to be crucial in triggering the transition from casual to compulsive drug-taking. Accordingly, we detected compulsive-like feeding behavior in obese but not lean rats, measured as palatable food consumption that was resistant to disruption by an aversive conditioned stimulus. Striatal dop ...[more]