Ontology highlight
ABSTRACT:
SUBMITTER: Cho DH
PROVIDER: S-EPMC2823371 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Cho Dong-Hyung DH Nakamura Tomohiro T Fang Jianguo J Cieplak Piotr P Godzik Adam A Gu Zezong Z Lipton Stuart A SA
Science (New York, N.Y.) 20090401 5923
Mitochondria continuously undergo two opposing processes, fission and fusion. The disruption of this dynamic equilibrium may herald cell injury or death and may contribute to developmental and neurodegenerative disorders. Nitric oxide functions as a signaling molecule, but in excess it mediates neuronal injury, in part via mitochondrial fission or fragmentation. However, the underlying mechanism for nitric oxide-induced pathological fission remains unclear. We found that nitric oxide produced in ...[more]