Ontology highlight
ABSTRACT:
SUBMITTER: Kramer S
PROVIDER: S-EPMC2823576 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Kramer Susanne S Queiroz Rafael R Ellis Louise L Hoheisel Jörg D JD Clayton Christine C Carrington Mark M
Journal of cell science 20100202 Pt 5
In trypanosomes, the predominant mechanisms of regulation of gene expression are post-transcriptional. The DEAD-box RNA helicase DHH1 was identified in a screen for gene products that are necessary for the instability of the GPI-PLC mRNA in insect-stage trypanosomes. Expression of an ATPase-deficient dhh1 mutant caused a rapid growth arrest associated with a decrease in polysomes, an increase in P-bodies and a slight decrease in average mRNA levels. However, the effect of dhh1 mutant expression ...[more]