Ontology highlight
ABSTRACT:
SUBMITTER: Joiner ML
PROVIDER: S-EPMC2824466 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
The EMBO journal 20091126 2
Central noradrenergic signalling mediates arousal and facilitates learning through unknown molecular mechanisms. Here, we show that the beta(2)-adrenergic receptor (beta(2)AR), the trimeric G(s) protein, adenylyl cyclase, and PKA form a signalling complex with the AMPA-type glutamate receptor subunit GluR1, which is linked to the beta(2)AR through stargazin and PSD-95 and their homologues. Only GluR1 associated with the beta(2)AR is phosphorylated by PKA on beta(2)AR stimulation. Peptides that i ...[more]