Ontology highlight
ABSTRACT:
SUBMITTER: Fumagalli M
PROVIDER: S-EPMC2824813 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Fumagalli Matteo M Pozzoli Uberto U Cagliani Rachele R Comi Giacomo P GP Bresolin Nereo N Clerici Mario M Sironi Manuela M
PLoS genetics 20100219 2
Viruses have exerted a constant and potent selective pressure on human genes throughout evolution. We utilized the marks left by selection on allele frequency to identify viral infection-associated allelic variants. Virus diversity (the number of different viruses in a geographic region) was used to measure virus-driven selective pressure. Results showed an excess of variants correlated with virus diversity in genes involved in immune response and in the biosynthesis of glycan structures functio ...[more]