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Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.

ABSTRACT: Adverse drug reactions (ADRs) are a significant source of patient morbidity and mortality and represent a major burden to health care systems and drug development. Up to 50% of such reactions are preventable. Although many ADRs can be predicted based on the on-target pharmacologic activity, ADRs arising from drug interactions with off-target receptors are recognized. Off-target ADRs include the immune-mediated ADRs (IM-ADRs) and pharmacologic drug effects. In this review, we discuss what is known about the immunogenetics and pathogenesis of IM-ADRs and the hypothesized role of heterologous immunity in the development of IM-ADRs.

SUBMITTER: Pavlos R

PROVIDER: S-EPMC5702581 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.

Pavlos Rebecca R White Katie D KD Wanjalla Celestine C Mallal Simon A SA Phillips Elizabeth J EJ

Immunology and allergy clinics of North America 20171101 4

Adverse drug reactions (ADRs) are a significant source of patient morbidity and mortality and represent a major burden to health care systems and drug development. Up to 50% of such reactions are preventable. Although many ADRs can be predicted based on the on-target pharmacologic activity, ADRs arising from drug interactions with off-target receptors are recognized. Off-target ADRs include the immune-mediated ADRs (IM-ADRs) and pharmacologic drug effects. In this review, we discuss what is know ...[more]

PMID: 28965641

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