Ontology highlight
ABSTRACT:
SUBMITTER: Cao P
PROVIDER: S-EPMC2824852 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Cao Pengxiu P Yuan Yiyuan Y Pehek Elizabeth A EA Moise Alex R AR Huang Ying Y Palczewski Krzysztof K Feng Zhaoyang Z
PloS one 20100219 2
Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human alpha-synuclein in C. elegans results in dopaminergic neuron degeneration, the effects of alpha-synuclein on dopamine homeostasis and its contribution to dopaminergic neuron degeneration in C. elegans have not been reported. Here, we examined the effects of alpha-synuclein overexpression on ...[more]