Ontology highlight
ABSTRACT:
SUBMITTER: Marrocco E
PROVIDER: S-EPMC7295803 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Marrocco Elena E Indrieri Alessia A Esposito Federica F Tarallo Valeria V Carboncino Anna A Alvino Filomena Grazia FG De Falco Sandro S Franco Brunella B De Risi Maria M De Leonibus Elvira E
Scientific reports 20200615 1
The presence of α-synuclein aggregates in the retina of Parkinson's disease patients has been associated with vision impairment. In this study we sought to determine the effects of α-synuclein overexpression on the survival and function of dopaminergic amacrine cells (DACs) in the retina. Adult mice were intravitreally injected with an adeno-associated viral (AAV) vector to overexpress human wild-type α-synuclein in the inner retina. Before and after systemic injections of levodopa (L-DOPA), ret ...[more]