Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans.

ABSTRACT:

Introduction

The 11q23.1 genomic region has been associated with nicotine dependence in Black and White Americans.

Methods

By conducting linkage disequilibrium analyses of 7 informative single nucleotide polymorphisms (SNPs) within the tetratricopeptide repeat domain 12 (TTC12)/ankyrin repeat and kinase containing 1 (ANKK1)/dopamine (D2) receptor gene cluster, we identified haplotype block structures in 270 Black and 368 White (n = 638) participants, from the Baltimore Epidemiologic Catchment Area cohort study, spanning the TTC12 and ANKK1 genes consisting of three SNPs (rs2303380-rs4938015-rs11604671). Informative haplotypes were examined for sex-specific associations with daily tobacco smoking initiation and cessation using longitudinal data from 1993-1994 and 2004-2005 in

SUBMITTER: David SP 

PROVIDER: S-EPMC2825103 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature