Ontology highlight
ABSTRACT:
SUBMITTER: Wernick NL
PROVIDER: S-EPMC2825409 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Wernick Naomi L B NL De Luca Heidi H Kam Wendy R WR Lencer Wayne I WI
The Journal of biological chemistry 20100107 9
Cholera toxin travels from the plasma membrane to the endoplasmic reticulum of host cells, where a portion of the toxin, the A1-chain, is unfolded and targeted to a protein-conducting channel for retrotranslocation to the cytosol. Unlike most retrotranslocation substrates, the A1-chain escapes degradation by the proteasome and refolds in the cytosol to induce disease. How this occurs remains poorly understood. Here, we show that an unstructured peptide appended to the N terminus of the A1-chain ...[more]