Ontology highlight
ABSTRACT:
SUBMITTER: Taylor M
PROVIDER: S-EPMC2951200 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Taylor Michael M Navarro-Garcia Fernando F Huerta Jazmin J Burress Helen H Massey Shane S Ireton Keith K Teter Ken K
The Journal of biological chemistry 20100728 41
Cholera toxin (CT) is an AB(5) toxin that moves from the cell surface to the endoplasmic reticulum (ER) by retrograde vesicular transport. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin and enters the cytosol by exploiting the quality control system of ER-associated degradation (ERAD). The driving force for CTA1 dislocation into the cytosol is unknown. Here, we demonstrate that the cytosolic chaperone Hsp90 is required for CTA1 passage into the cytosol. Hsp90 bound to ...[more]