Ontology highlight
ABSTRACT:
SUBMITTER: Capaldi AP
PROVIDER: S-EPMC2825711 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Capaldi Andrew P AP Kaplan Tommy T Liu Ying Y Habib Naomi N Regev Aviv A Friedman Nir N O'Shea Erin K EK
Nature genetics 20081019 11
Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and cr ...[more]