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A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response.


ABSTRACT: Kruppel-like factor 6 (KLF6) is a tumor suppressor gene that is functionally inactivated in human cancer by loss of heterozygosity, somatic mutation, decreased expression, and increased alternative splicing into an oncogenic splice variant, KLF6-SV1. Here we show that increased expression of KLF6-SV1 is associated with decreased survival in patients with lung adenocarcinoma. In addition, KLF6-SV1 is a novel antiapoptotic protein in lung cancer cell lines, and targeted reduction of KLF6-SV1 using siRNA induces apoptosis both alone and in combination with the chemotherapeutic drug cisplatin. Together, these findings highlight a critical role for KLF6-SV1 in lung cancer, and show a potential novel therapeutic strategy for the treatment of lung cancer.

SUBMITTER: DiFeo A 

PROVIDER: S-EPMC2826216 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature

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A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response.

DiFeo Analisa A   Feld Lauren L   Rodriguez Estefania E   Wang Christine C   Beer David G DG   Martignetti John A JA   Narla Goutham G  

Cancer research 20080204 4


Kruppel-like factor 6 (KLF6) is a tumor suppressor gene that is functionally inactivated in human cancer by loss of heterozygosity, somatic mutation, decreased expression, and increased alternative splicing into an oncogenic splice variant, KLF6-SV1. Here we show that increased expression of KLF6-SV1 is associated with decreased survival in patients with lung adenocarcinoma. In addition, KLF6-SV1 is a novel antiapoptotic protein in lung cancer cell lines, and targeted reduction of KLF6-SV1 using  ...[more]

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