Ontology highlight
ABSTRACT:
SUBMITTER: Sangodkar J
PROVIDER: S-EPMC2831196 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Sangodkar Jaya J DiFeo Analisa A Feld Lauren L Bromberg Romina R Schwartz Rachel R Huang Fei F Terzo Esteban A EA Choudhri Aisha A Narla Goutham G
Lung cancer (Amsterdam, Netherlands) 20090328 3
Kruppel-like factor 6 splice variant 1 (KLF6-SV1) is an oncogenic splice variant of the KLF6 tumor suppressor gene that is specifically overexpressed in a number of human cancers. Previously, we have demonstrated that increased expression of KLF6-SV1 is associated with decreased survival in lung adenocarcinoma patient samples and that targeted reduction of KLF6-SV1 using siRNA induced apoptosis both alone and in combination with the chemotherapeutic drug cisplatin. Here, we demonstrate that chem ...[more]