Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.
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ABSTRACT:
SUBMITTER: Pan D
PROVIDER: S-EPMC2826244 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.
Pan Dipanjan D Williams Todd A TA Senpan Angana A Allen John S JS Scott Mike J MJ Gaffney Patrick J PJ Wickline Samuel A SA Lanza Gregory M GM
Journal of the American Chemical Society 20091001 42
A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nan ...[more]
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