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Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.

ABSTRACT: A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

SUBMITTER: Pan D

PROVIDER: S-EPMC2826244 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.

Pan Dipanjan D Williams Todd A TA Senpan Angana A Allen John S JS Scott Mike J MJ Gaffney Patrick J PJ Wickline Samuel A SA Lanza Gregory M GM

Journal of the American Chemical Society 20091001 42

A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nan ...[more]

PMID: 19795893

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