Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations.
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ABSTRACT:
SUBMITTER: Ganesh AN
PROVIDER: S-EPMC5548416 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations.
Ganesh Ahil N AN Logie Jennifer J McLaughlin Christopher K CK Barthel Benjamin L BL Koch Tad H TH Shoichet Brian K BK Shoichet Molly S MS
Molecular pharmaceutics 20170519 6
While limited drug loading continues to be problematic for chemotherapeutics formulated in nanoparticles, we found that we could take advantage of colloidal drug aggregation to achieve high loading when combined with polymeric excipients. We demonstrate this approach with two drugs, fulvestrant and pentyl-PABC doxazolidine (PPD; a prodrug of doxazolidine, which is a DNA cross-linking anthracycline), and two polymers, polysorbate 80 (UP80) and poly(d,l-lactide-co-2-methyl-2-carboxytrimethylene ca ...[more]
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