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Ubiquitination and degradation of the inhibitors of NF-kappaB.

ABSTRACT: The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery.

SUBMITTER: Kanarek N

PROVIDER: S-EPMC2828279 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Ubiquitination and degradation of the inhibitors of NF-kappaB.

Kanarek Naama N London Nir N Schueler-Furman Ora O Ben-Neriah Yinon Y

Cold Spring Harbor perspectives in biology 20100201 2

The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we revi ...[more]

PMID: 20182612

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