Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.
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ABSTRACT:
SUBMITTER: Mu J
PROVIDER: S-EPMC2828519 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
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Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.
Mu Jianbing J Myers Rachel A RA Jiang Hongying H Liu Shengfa S Ricklefs Stacy S Waisberg Michael M Chotivanich Kesinee K Wilairatana Polrat P Krudsood Srivicha S White Nicholas J NJ Udomsangpetch Rachanee R Cui Liwang L Ho May M Ou Fengzhen F Li Haibo H Song Jianping J Li Guoqiao G Wang Xinhua X Seila Suon S Sokunthea Sreng S Socheat Duong D Sturdevant Daniel E DE Porcella Stephen F SF Fairhurst Rick M RM Wellems Thomas E TE Awadalla Philip P Su Xin-zhuan XZ
Nature genetics 20100131 3
Antimalarial drugs impose strong selective pressure on Plasmodium falciparum parasites and leave signatures of selection in the parasite genome; screening for genes under selection may suggest potential drug or immune targets. Genome-wide association studies (GWAS) of parasite traits have been hampered by the lack of high-throughput genotyping methods, inadequate knowledge of parasite population history and time-consuming adaptations of parasites to in vitro culture. Here we report the first Pla ...[more]
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