Ontology highlight
ABSTRACT:
SUBMITTER: Hautbergue GM
PROVIDER: S-EPMC2828547 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Hautbergue Guillaume M GM Hung Ming-Lung ML Walsh Matthew J MJ Snijders Ambrosius P L AP Chang Chung-Te CT Jones Rachel R Ponting Chris P CP Dickman Mark J MJ Wilson Stuart A SA
Current biology : CB 20091201 22
Messenger RNA (mRNA) export adaptors play an important role in the transport of mRNA from the nucleus to the cytoplasm. They couple early mRNA processing events such as 5' capping and 3' end formation with loading of the TAP/NXF1 export receptor onto mRNA. The canonical adaptor REF/ALY/Yra1 is recruited to mRNA via UAP56 and subsequently delivers the mRNA to NXF1 [1]. Knockdown of UAP56 [2, 3] and NXF1 [4-7] in higher eukaryotes efficiently blocks mRNA export, whereas knockdown of REF only cause ...[more]