Ontology highlight
ABSTRACT:
SUBMITTER: Stubbs SH
PROVIDER: S-EPMC3302444 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Stubbs Sarah H SH Hunter Olga V OV Hoover Ashley A Conrad Nicholas K NK
Molecular and cellular biology 20120130 7
TREX is a conserved multiprotein complex that is necessary for efficient mRNA export to the cytoplasm. In Saccharomyces cerevisiae, the TREX complex is additionally implicated in RNA quality control pathways, but it is unclear whether this function is conserved in mammalian cells. The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein binds and recruits the TREX component REF/Aly to viral mRNAs. Here, we demonstrate that REF/Aly is recruited to the KSHV noncoding polyadenylated nuclear ...[more]