Ontology highlight
ABSTRACT:
SUBMITTER: Castanier C
PROVIDER: S-EPMC2828750 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Castanier Céline C Garcin Dominique D Vazquez Aimé A Arnoult Damien D
EMBO reports 20091218 2
The intracellular retinoic acid-inducible gene I-like receptors (RLRs) sense viral ribonucleic acid and signal through the mitochondrial protein mitochondrial antiviral signalling (MAVS) to trigger the production of type I interferons and proinflammatory cytokines. In this study, we report that RLR activation promotes elongation of the mitochondrial network. Mimicking this elongation enhances signalling downstream from MAVS and favours the binding of MAVS to stimulator of interferon genes, an en ...[more]