Ontology highlight
ABSTRACT:
SUBMITTER: Soliman F
PROVIDER: S-EPMC2829261 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100114 5967
Mouse models are useful for studying genes involved in behavior, but whether they are relevant to human behavior is unclear. Here, we identified parallel phenotypes in mice and humans resulting from a common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, which is involved in anxiety-related behavior. An inbred genetic knock-in mouse strain expressing the variant BDNF recapitulated the phenotypic effects of the human polymorphism. Both were impaired in exting ...[more]