Ontology highlight
ABSTRACT:
SUBMITTER: Inman WD
PROVIDER: S-EPMC2829331 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Inman Wayne D WD Bray Walter M WM Gassner Nadine C NC Lokey R Scott RS Tenney Karen K Shen Young Yongchun YY Tendyke Karen K Suh Ted T Crews Phillip P
Journal of natural products 20100201 2
A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lin ...[more]