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Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.

ABSTRACT: Four new bisabolane sesquiterpenes, altaicalarins A-D (1-4), and three known analogues (5-7) were isolated from the roots and rhizomes of Ligularia altaica. The structures were elucidated by spectroscopic methods including 2D NMR techniques, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The isolated compounds were also evaluated for cytotoxic activity against human lung carcinoma (A-549), human breast adenocarcinoma (MCF-7), epidermoid carcinoma of the nasopharynx (KB), and vincristine-resistant nasopharyngeal (KBVIN) cell lines, and 1 was found to show significant cytotoxicity, with EC(50) values of 3.4, 0.8, 1.0, and 0.9 microg/mL, respectively.

SUBMITTER: Wang Q

PROVIDER: S-EPMC2829383 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.

Wang Qi Q Chen Tzu-Hsuan TH Bastow Kenneth F KF Lee Kuo-Hsiung KH Chen Dao-Feng DF

Journal of natural products 20100201 2

Four new bisabolane sesquiterpenes, altaicalarins A-D (1-4), and three known analogues (5-7) were isolated from the roots and rhizomes of Ligularia altaica. The structures were elucidated by spectroscopic methods including 2D NMR techniques, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The isolated compounds were also evaluated for cytotoxic activity against human lung carcinoma (A-549), human breast adenocarcinoma (MCF-7), epidermoid carcinoma of the nasopharynx (KB ...[more]

PMID: 20073490

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