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Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.

ABSTRACT: Five new highly oxygenated oplopane sesquiterpenes, songaricalarins A-E (1-5), and two known analogues (6 and 7) were isolated from the roots and rhizomes of Ligularia songarica. Their structures and configurations were elucidated by spectroscopic methods, including 2D-NMR techniques, and the structure of 1 was confirmed by single-crystal X-ray diffraction. All compounds were evaluated for in vitro cytotoxic activity against cultured A-549, MCF-7, KB, and KBVIN cells, and 4 exhibited cytotoxicity with EC50 values of 4.9, 0.8, 3.4, and 3.2 ?g/mL, respectively.

SUBMITTER: Wang Q

PROVIDER: S-EPMC3553309 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.

Wang Qi Q Chen Tzu-Hsuan TH Bastow Kenneth F KF Morris-Natschke Susan L SL Lee Kuo-Hsiung KH Chen Dao-Feng DF

Journal of natural products 20121008 3

Five new highly oxygenated oplopane sesquiterpenes, songaricalarins A-E (1-5), and two known analogues (6 and 7) were isolated from the roots and rhizomes of Ligularia songarica. Their structures and configurations were elucidated by spectroscopic methods, including 2D-NMR techniques, and the structure of 1 was confirmed by single-crystal X-ray diffraction. All compounds were evaluated for in vitro cytotoxic activity against cultured A-549, MCF-7, KB, and KBVIN cells, and 4 exhibited cytotoxicit ...[more]

PMID: 23043462

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