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Rapid dissemination of newly introduced Plasmodium vivax genotypes in South Korea.


ABSTRACT: Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.

SUBMITTER: Choi YK 

PROVIDER: S-EPMC2829904 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Rapid dissemination of newly introduced Plasmodium vivax genotypes in South Korea.

Choi Yien-Kyoung YK   Choi Kyung-Mi KM   Park Mi-Hyun MH   Lee Eun-Gyu EG   Kim Yeon-Joo YJ   Lee Byeong-Chul BC   Cho Shin-Hyung SH   Rhie Ho-Gun HG   Lee Ho-Sa HS   Yu Jae-Ran JR   Lee Joo-Shil JS   Kim Tong-Soo TS   Kim Jung-Yeon JY  

The American journal of tropical medicine and hygiene 20100301 3


Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recent  ...[more]

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