Ontology highlight
ABSTRACT:
SUBMITTER: Cannons JL
PROVIDER: S-EPMC2830297 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Cannons Jennifer L JL Qi Hai H Lu Kristina T KT Dutta Mala M Gomez-Rodriguez Julio J Cheng Jun J Wakeland Edward K EK Germain Ronald N RN Schwartzberg Pamela L PL
Immunity 20100211 2
CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained unclear. We found that whereas T cell:DC interactions were primarily integrin dependent, T cell:B cell interactions had both an early integrin-dependent phase and a sustained phase t ...[more]