Ontology highlight
ABSTRACT:
SUBMITTER: Cho JH
PROVIDER: S-EPMC2830358 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Cho Jae-Ho JH Kim Hee-Ok HO Surh Charles D CD Sprent Jonathan J
Immunity 20100204 2
T cell receptor (TCR) contact with self ligands keeps T cells alive and is shown here to cause naive CD8(+), but not CD4(+), T cells to be hypersensitive to certain gamma(c) cytokines, notably interleukin (IL)-2, IL-15, and IL-7. Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts. By contrast, CD4(+) T cells expressed low amounts of GM1 and wer ...[more]